There was only one adverse (gastrointestinal) event in the 602 participants who underwent the CoQ10 intervention. The results of our meta-regression demonstrate that increases in the daily dose (coefficient = −0.0017 per mg, p < 0.001) and treatment duration (coefficient = −0.0042 per day, p = 0.007) of CoQ10 supplementation were correlated with greater fatigue reduction. Compared with the placebo group, the effect of reducing fatigue was statistically significant in the subgroup using the CoQ10-only formulation but not in the subgroup using CoQ10 compounds. The directions of the treatment effects were consistent between the healthy and diseased participants. As compared with the placebo groups evaluated in each RCT, the CoQ10 group showed a statistically significant reduction in fatigue scores (Hedges’ g = −0.398, 95% confidence interval = −0.641 to −0.155, p = 0.001). A random effects model was implemented to conduct the meta-analysis among 13 RCTs (with a total of 1,126 participants). More specifically, we searched electronic databases for randomized controlled trials (RCTs) published from the database inception to January 2022. Hence, we conducted this meta-analysis with the aim of investigating the effectiveness of fatigue reduction via CoQ10 supplementation. However, the data on this topic has been sparse to date. Several clinical studies have suggested that fatigue can be reduced by antioxidant supplementation. 14Center for Regional Anesthesia and Pain Medicine, Wang-Fang Hospital, Taipei Medical University, Taipei, TaiwanĬoenzyme Q10 (CoQ10) is a popular nutritional supplement, an antioxidant and an essential component of the mitochondrial electron transport chain.13Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan.12Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. ![]() 11Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan. ![]()
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